Retreats at Shellbourne Conference Center are traditional, silent retreats, conducted by priests of the Prelature of Opus Dei for either men or women. The conference center, located on 40 wooded acres in northern Indiana, includes two chapels, a dining room, living rooms, class rooms, and 60 individual bedroooms. Walking trails and a separate shrine dedicated to the Blessed Virgin help those attending the retreat to maintain a spirit of prayer and recollection.

Each day of the retreat includes Holy Mass, four or five conferences given by the priest, Exposition and Benediction of the Blessed Sacrament and recitation of the rosary. The priest conducting the retreat is available for the Sacrament of Reconciliation as well as for personal consultation.

Each participant has a private bedroom for his or her use. All meals are provided in family style and special dietary restrictions can be accommodated.

Often two retreats are held simultaneously, one in the Main House and one in the Lodge.